- A Case of Hepatocellular Carcinoma Exhibited over Partial Response after Hepatic Arterial Infusion Chemotherapy
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Chang Wook Park, Young Lan Kown, Yong Jin Kim, Yoon Jung Kim, Hye Jin Seo, Kyung In Lee, Eun Soo Kim, Byung Kook Jang, Woo Jin Jeong, Kyung Sik Park, Kwang Bum Jo, Jae Seok Hwang, Young Hwan Kim, Jung Hyuk Kwon
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Journal of the Korean Liver Cancer Study Group. 2010;10(1):40-43. Published online June 30, 2010
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Abstract
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- Hepatocellular carcinoma (HCC) is one of the cancers with poor prognosis. Especially potal vein invasion is a grave
prognostic indicator in the setting of HCC. There is currently no effective method for treatment of HCC with portal vein
invasion. A 61-year-old female patient was diagnosed a massive HCCs in both hepatic lobe with portal vein thrombosis,
based on computed tomography (CT) and increased tumor marker, α-fetoprotein. She was treated with intrahepatic arterial
CDDP (10 mg on 1~5 day), 5-FU (250mg on 1~5 day) and leukovorin (12mg on 1~5 day) infusion via percutaneously
implantable port system (PIPS) every 3 weeks, totally seven times. The patient was still living 6 months after first hepatic
arterial infusion chemotherapy (HAIC) and follow-up CT showed partial response with necrosis of HCCs. We report here
a case of advanced HCC with portal vein thrombosis that was effectively treated with HAIC via PIPS.
- A Case of Hepatocellular Carcinoma Presenting with Rib Metastasis
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Kyung In Lee, Young Lan Kwon, Yoon Jung Kim, Hye Jin Seo, Yong Jin Kim, Chang Wook Park, Eun Soo Kim, Byoung Kuk Jang, Woo Jin Chung, Kyung Sik Park, Kwang Bum Cho, Jae Seok Hwang, Jung Hyeok Kwon
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Journal of the Korean Liver Cancer Study Group. 2010;10(1):64-68. Published online June 30, 2010
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Abstract
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- Bone metastasis is not uncommon and shows poor survival in patients with hepatocellular carcinoma (HCC). We describe
a case of HCC presenting with rib metastasis in a 54-year-old man. In spite of radiotherapy for rib metastasis, pain was
sustained and size of lesions were increased. So we performd CT-guided percutaneous ethanol injection therapy (PEIT).
Whenever new metastatic bone lesions were detected, we have done PEIT. However, abdominal CT scan at 25th month after
diagnosis shows residual viable tumors in pelvic bone and multiple metastatic nodules in both lung. He is alive by taking
conservative management for 27 months after diagnosis.
- A Case of Curative Resection of Advanced Hepatocellular Carcinoma After Localized Concurrent Chemo-Radiation Therapy
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Jee Suk Kwon, Jeong Eun Lee, Woo Young Park, Kyung In Lee, Eun Soo Kim, Byoung Kuk Jang, Woo Jin Chung, Kyung Sik Park, Kwang Bum Cho, Jaeseok Hwang
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Journal of the Korean Liver Cancer Study Group. 2009;9(1):67-70. Published online June 30, 2009
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Abstract
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- Advanced hepatocellular carcinoma (HCC) with portal vein thrombosis is not suitable candidates for surgical treatment at
the most of diagnosis because of poor liver function, extensive tumor involvement of the liver, vascular involvement, and/or
intra/extrahepatic metastasis. We attempted localized concurrent chemo-radiation therapy (CCRT) in patients having locally
advanced HCC with left and main portal vein thrombosis. We report a case of locally advanced HCC patient who became
surgically resectable by downstaging after localized CCRT. Localized CCRT was performed with a total radiation dose of
5,040 cGy (180 cGy×28 times) and hepatic arterial infusion of 5-fluorouracil (5-FU, 250 mg/day) and cisplatin (10 mg/day)
for 5 days via implantable port system during the second and the fifth weeks of the radiotherapy. Marked contraction of HCC
was noted on follow up computerized tomography (CT) after localized CCRT, and subsequently surgical resection with
curative aim was performed. He was gave a additional transcatheter arterial chemoembolization (TACE) because follow up
CT revealed intrahepatic metastasis at subcapsular portion of right hepatic lobe after 3 months of operation. The patient is
in complete remission status without recurrence to date.
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